Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and https://kissbrides.com/iraqi-brides/ students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Biological needs and you may pharmacology from curcumin
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin is the biggest component of new red-colored color out-of turmeric, a keen Indian spruce which is taken from new rhizome of your exotic bush Curcuma longa, hence is one of the Zingiberaceae members of the family. Inside part, we talk about the pharmacological affairs from curcumin and you will talk about the new unit angles of these things. I next remark brand new shown and you will possible medical uses from curcumin. Curcumin known over the years since the a therapeutic representative, however, the process regarding action was outlined. The fresh pharmacological outcomes of curcumin seem to be the result of an effective synergism away from communities away from weak biochemical connections that have numerous physiological purpose from inside the interrelated signaling paths. These types of plans include minerals like cyclooxygenase, lipoxygenase and protein kinases, and you will transcription activities instance NF-?B, STAT and Nrf2. Modulation of them molecules has an effect on downstream affectors which make the new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you may antimicrobial circumstances regarding curcumin. This type of effects had been checked-out during the medical samples away from curcumin to possess discomfort and inflammatory infection, cancer, Alzheimer state, cardiovascular sickness, and you can all forms of diabetes. The examples have used varying amounts regarding curcuminwith various other frequencies and you may period, towards standard conclusion that highest amounts of curcumin from the level of grams are required to receive therapeutic outcomes. Read more
Curcumin: Synthesis, Growing Part for the Pain Government and you may Health Effects
Guide Part Types of plant-derived pharmaceuticals that have get to be the desire away from continuing and you may exponential browse and you may creativity interest have, yet, come some scarce. Immediately following several years, the past two decades was in fact characterized by good 100-bend increase in how many scientific stuff published annually that try out of relevance for the entry to curcumin from inside the biomedicine. Read more
Design, synthesis and biological products out-of curcumin prodrugs
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has some prospective pharmacological consequences and may provides therapeutic applications in lots of problem states, because chatted about in more detail in the previous chapter. However, the possibility systematic effectiveness away from curcumin is bound of the its physicochemical services regarding terrible drinking water solubility and you will instability, and that trigger low bioavailability. Prodrugs from curcumin offer an approach to improvement of your own biopharmaceutical and you will pharmacokinetic features, that can make it exploitation of pharmacological aftereffects of curcumin. Inside chapter, we basic remark the physicochemical and pharmacokinetics regarding curcumin. I after that explain the appearance of curcumin prodrugs that have increased liquid solubility and you can improved chemical compounds balances which may be converted back again to free curcumin up on bioactivation from inside the vivo. I focus on present victory in this field, with a focus on the structure, synthesis and you can testing from prodrugs according to promoieties and amino acids, essential fatty acids, nucleic acids, dicarboxylic acids, and you can polymeric information such hyaluronic acidic and you may polyethylene glycol. Which part comes with the cause for optimisation of your own physicochemical and you may biopharmaceutical features additionally the physiological affairs regarding curcumin prodrugs, towards purpose using of them curcumin types inside logical apps. Read more